Desferal (Deferoxamine Mesylate) Dosage Calculator




Ref: https://www.novartis.com/us-en/sites/novartis_us/files/desferal.pdf

*This Desferal Dosage Calculator is only for reference. Please make sure you speak to your doctor before starting Desferal or changing your dosage and iron chelation program.

You can also check your Exjade and Jadenu dosage using this calculator.

Key Blood Tests & Monitoring Required

1. Serum Ferritin Levels

  • Why? To assess iron overload and monitor treatment effectiveness.
  • Frequency: Every 1 to 3 months.

Learn about IP6 and its role in reducing iron in my detailed article.

2. Complete Blood Count (CBC)

  • Why? To detect anemia, leukopenia, or thrombocytopenia.
  • Frequency: Every 3 to 6 months or as needed.

3. Serum Iron & Total Iron-Binding Capacity (TIBC)

  • Why? To monitor iron metabolism and iron overload.
  • Frequency: Periodically, based on clinical need.

Read my article on how green tea can help reduce iron absorption.

4. Liver Function Tests (LFTs – ALT, AST, Bilirubin, etc.)

  • Why? To detect liver toxicity, especially in iron overload conditions.
  • Frequency: Every 3 to 6 months.

5. Kidney Function Tests (Creatinine, BUN, Electrolytes, Urinalysis)

  • Why? Deferoxamine can affect kidney function, especially with long-term use.
  • Frequency: Every 3 to 6 months.

6. Audiometry (Hearing Test)

  • Why? Deferoxamine can cause ototoxicity (hearing loss, tinnitus), especially with high doses.
  • Frequency: Every 6-12 months (more frequently in children or at high doses).

7. Ophthalmologic Exam (Eye Check-Up for Retinal Toxicity & Visual Acuity)

  • Why? Risk of retinal and visual changes (e.g., night blindness, color vision issues).
  • Frequency: Every 6-12 months.

8. Zinc & Vitamin C Levels

  • Why? Deferoxamine therapy can deplete zinc, and Vitamin C enhances iron chelation but must be used cautiously.
  • Frequency: As clinically indicated.

Additional Monitoring Considerations

  • Growth & Development in Children:
    • Long-term Deferoxamine use can affect growth, so regular height & weight tracking is needed.
  • Cardiac MRI (T2 MRI) for Iron Overload in the Heart:*
    • For patients with severe iron overload, this is done yearly to assess cardiac iron deposition.
  • Bone Health (DEXA Scan for Osteoporosis)
    • Chronic iron overload and long-term Desferal use can affect bone density.

What You Should Do