Exjade and Jadenu Dosage Calculator

Ref:

https://www.novartis.com/sg-en/sites/novartis_sg/files/Jadenu-Jul2019.SINv1-app170322-pdf.pdf

https://www.novartis.com/us-en/sites/novartis_us/files/exjade.pdf

*This Exjade and Jadenu Dosage Calculator is only for reference. Please make sure you speak to your doctor before starting or changing your dosage and iron chelation program.

You can also check your Desferal dosage using this calculator.

Required Blood Tests and Monitoring for Jadenu & Exjade

Test Reason for Monitoring Frequency
Serum Ferritin To assess iron overload and ensure proper chelation dose adjustment Monthly
Liver Function Tests (ALT, AST, Bilirubin, ALP, etc.) To monitor for liver toxicity, which may occur with deferasirox therapy Baseline and at least every 2 months
Serum Creatinine & eGFR (Glomerular Filtration Rate) To monitor kidney function and detect renal impairment Baseline, then at least monthly (weekly in high-risk patients)
Creatinine Clearance (in adults) To assess kidney function, especially in patients at risk of renal toxicity Baseline, then at least monthly
Urine Protein & Urinalysis To detect proteinuria, which may indicate kidney damage Baseline, then monthly
Complete Blood Count (CBC) with Differential & Platelets To monitor for cytopenias (e.g., anemia, neutropenia, thrombocytopenia), which can be a side effect of deferasirox Baseline, then monthly
Serum Electrolytes (Potassium, Sodium, Calcium, etc.) To monitor for electrolyte imbalances that may occur due to kidney dysfunction Baseline, then periodically
Hearing Tests (Audiometry) To check for potential auditory toxicity (hearing loss), which has been reported with long-term therapy Baseline, then annually or if symptoms arise
Ophthalmologic Examination (Eye Exam) To monitor for ocular toxicity, including lens opacities (cataracts) or retinal changes Baseline, then annually or if symptoms arise


Did you know there are natural iron chelators that you can add to your diet to improve your iron chelation?

Check out this article on the 4 Great Natural Iron Chelators

Additional Considerations

  • Overchelation Risk: If serum ferritin falls below 500 mcg/L, treatment should be interrupted to prevent excessive iron removal.
  • High-Risk Patients (elderly, pre-existing renal or hepatic impairment, concomitant medications affecting kidney/liver function) should undergo more frequent monitoring.
  • Dose Adjustments:
    • Increase or decrease deferasirox doses in 5-10 mg/kg increments based on ferritin trends and patient response.
    • If serum ferritin falls below 1000 mcg/L at two consecutive visits, consider dose reduction.

What You Should Do